重磅综述：mRNA疫苗全面解读
<div style="max-width:100%;overflow:hidden;"><p><br></p><section style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;font-style: normal;font-variant-ligatures: normal;font-variant-caps: normal;font-weight: 400;letter-spacing: 0.544px;orphans: 2;text-align: justify;text-indent: 0px;text-transform: none;white-space: normal;widows: 2;word-spacing: 0px;-webkit-text-stroke-width: 0px;text-decoration-style: initial;text-decoration-color: initial;background-color: rgb(255, 255, 255);font-size: 14px;visibility: visible;"><section powered-by="xiumi.us" style="margin: 10px 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;visibility: visible;"><section style="margin: 0px;padding: 0px 1em;outline: 0px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;display: inline-block;text-align: center;visibility: visible;"><span title="" opera-tn-ra-cell="_$.pages:0.layers:0.comps:0.title1" style="margin: 0px;padding: 0.3em 0.5em;outline: 0px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;display: inline-block;border-radius: 0.5em;font-size: 12px;text-shadow: rgb(204, 204, 204) 4px 3px;color: rgb(95, 156, 239);visibility: visible;"><p style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;clear: both;min-height: 1em;visibility: visible;"><span style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 15px;visibility: visible;"><strong style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible;">文章摘要</strong></span><strong style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;visibility: visible;"></strong></p></span></section><section style="margin: -1em 0px 0px;padding: 20px 10px 10px;outline: 0px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;border-width: 1px;border-style: solid;border-color: rgb(192, 200, 209);background-color: rgb(239, 239, 239);text-align: center;visibility: visible;"><section powered-by="xiumi.us" style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;text-align: justify;visibility: visible;"><section style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;line-height: 2em;visibility: visible;"><span style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 14px;letter-spacing: 0.5px;visibility: visible;">这篇综述全面描述了基于mRNA的治疗方法（图一），</span><span style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;letter-spacing: 0.5px;visibility: visible;">包括它们的原理、制造、应用、效果和缺点。同时也介绍了mRNA优化和传递系统在mRNA治疗中的重要性，并进一步讨论了mRNA对抗疾病所要面对的挑战和机遇。</span></section><p style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;clear: both;min-height: 1em;visibility: visible;"><br style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible;"></p><p style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;clear: both;min-height: 1em;line-height: 2em;visibility: visible;"><span style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 14px;letter-spacing: 0.5px;visibility: visible;">全文参考文献近600篇。内容较长，感兴趣的小伙伴，可以直接滑动到对应位置进行阅读：</span><br style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible;"></p><section style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;line-height: 2em;visibility: visible;"><strong style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible;"><span style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 14px;letter-spacing: 0.5px;visibility: visible;">一、mRNA的设计与制造</span></strong><span style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 14px;letter-spacing: 0.5px;visibility: visible;"></span></section><section style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;line-height: 2em;visibility: visible;"><span style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 14px;letter-spacing: 0.5px;color: rgb(0, 128, 255);visibility: visible;">涵盖内容</span><span style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 14px;letter-spacing: 0.5px;visibility: visible;">：mRNA的结构成分；mRNA翻译和衰变；mRNA设计；RNA化学式设计；mRNA的制造；mRNA纯化；</span></section><section style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;line-height: 2em;visibility: visible;"><strong style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible;"><span style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 14px;letter-spacing: 0.5px;visibility: visible;">二、mRNA运载系统</span></strong><span style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 14px;letter-spacing: 0.5px;visibility: visible;"></span></section><section style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;line-height: 2em;visibility: visible;"><span style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 14px;letter-spacing: 0.5px;color: rgb(0, 128, 255);visibility: visible;">涵盖内容</span><span style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 14px;letter-spacing: 0.5px;visibility: visible;">：mRNA运载体；影响mRNA运载的其他因素；</span></section><section style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;line-height: 2em;visibility: visible;"><strong style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible;"><span style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 14px;letter-spacing: 0.5px;visibility: visible;">三、mRNA治疗的应用</span></strong><span style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 14px;letter-spacing: 0.5px;visibility: visible;"></span></section><section style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;line-height: 2em;visibility: visible;"><span style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 14px;letter-spacing: 0.5px;color: rgb(0, 128, 255);visibility: visible;">涵盖内容</span><span style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 14px;letter-spacing: 0.5px;visibility: visible;">：直接基于编码分子的mRNA疗法；基于mRNA单克隆抗体及免疫疗法；mRNA癌症疫苗的耐受性及安全性；mRNA疫苗佐剂；基于mRNA的蛋白质替代疗法；mRNA编码肽及蛋白质；基于mRNA的基因编辑疗法及CRISPR / Cas核酸酶系统；</span><span style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;letter-spacing: 0.5px;visibility: visible;">基于mRNA的治疗。</span></section></section></section></section></section><p style="margin: 0px 8px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;clear: both;min-height: 1em;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;font-size: 17px;font-style: normal;font-variant-ligatures: normal;font-variant-caps: normal;font-weight: 400;letter-spacing: 0.544px;orphans: 2;text-align: justify;text-indent: 0px;text-transform: none;white-space: normal;widows: 2;word-spacing: 0px;-webkit-text-stroke-width: 0px;text-decoration-style: initial;text-decoration-color: initial;background-color: rgb(255, 255, 255);line-height: 2em;visibility: visible;"><span style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 15px;letter-spacing: 0.5px;visibility: visible;">伴随着全球的新冠大流行，新冠疫苗备受关注。目前市面上的新冠疫苗有三个类型：传统灭活疫苗、腺病毒载体疫苗以及信使RNA (mRNA)疫苗。传统的灭活疫苗我们比较了解，它是将经过处理、没有传染性和致病性的病原体注入人体，让免疫系统认识这种病原体，从而达到预防的目的。腺病毒载体疫苗是用另外一种非复制型的病毒将想要免疫的病原体DNA注入人体。相较于这两种疫苗，</span><span style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 15px;letter-spacing: 0.5px;color: rgb(0, 128, 255);">mRNA疫苗更具设计与制造的简便性、固有的免疫原性、快速量产性等优势。</span></p><p style="margin: 0px 8px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;clear: both;min-height: 1em;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;font-size: 17px;font-style: normal;font-variant-ligatures: normal;font-variant-caps: normal;font-weight: 400;letter-spacing: 0.544px;orphans: 2;text-align: justify;text-indent: 0px;text-transform: none;white-space: normal;widows: 2;word-spacing: 0px;-webkit-text-stroke-width: 0px;text-decoration-style: initial;text-decoration-color: initial;background-color: rgb(255, 255, 255);line-height: 2em;"><br style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;"></p><p style="margin: 0px 8px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;clear: both;min-height: 1em;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;font-size: 17px;font-style: normal;font-variant-ligatures: normal;font-variant-caps: normal;font-weight: 400;letter-spacing: 0.544px;orphans: 2;text-align: justify;text-indent: 0px;text-transform: none;white-space: normal;widows: 2;word-spacing: 0px;-webkit-text-stroke-width: 0px;text-decoration-style: initial;text-decoration-color: initial;background-color: rgb(255, 255, 255);line-height: 2em;"><span style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 15px;letter-spacing: 0.5px;">而且随着生物技术和分子医学的快速发展，mRNA引入人体作为疫苗或治疗剂能够产生几乎所有功能性蛋白，这代表着一个精准医学领域正在崛起，其在预防和治疗许多难治性疾病方面前景广阔。因此，小编今天和大家分享一篇今年五月刚刚发表在</span><span style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;letter-spacing: 0.5px;font-size: 14px;color: rgb(0, 128, 255);">Signal Transduction and Targeted Therapy</span><span style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 15px;letter-spacing: 0.5px;">杂志上</span><span style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;letter-spacing: 0.5px;font-size: 14px;color: rgb(0, 128, 255);">（IF:18.817）</span><span style="margin: 0px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 15px;letter-spacing: 0.5px;">的关于mRNA治疗的综述，为大家进一步介绍mRNA治疗的现状，感兴趣的小伙伴不要错过哟。</span></p><p style="margin: 0px 8px;padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;clear: both;min-height: 1em;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;font-size: 17px;font-style: normal;font-variant-ligatures: normal;font-variant-caps: normal;font-weight: 400;letter-spacing: 0.544px;orphans: 2;text-align: justify;text-indent: 0px;text-transform: none;white-space: normal;widows: 2;word-spacing: 0px;-webkit-text-stroke-width: 0px;text-decoration-style: initial;text-decoration-color: initial;background-color: rgb(255, 255, 255);line-height: 2em;">**** Hidden Message *****</p>
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